Lipid modulation of plasma membrane‐bound ATPases

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Abstract
The plasma membrane cation‐pumping ATPase is a key regulatory enzyme in cellular events. However, the mechanism by which its activity is controlled is still unclear. Lipid modulation is acknowledged to be a potentially important mechanism in this respect, although precisely how it is achieved remains controversial. This review examines the modulation of plant, animal, yeast and fungal plasma membrane‐bound ATPases by sterols and phospholipids as well as discussing critically two putative modulating mechanisms, the ‘Annulus Hypothesis’ and membrane fluidity. The use of xenobiotics in helping to elucidate the role played by lipids in ATPase regulation is examined and a sequence of events by which lipid modulation may occur is suggested.

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