Immunohistochemical Localization of T Antigen-Like Substance in Benign Hyperplasia and Adenocarcinoma of the Prostate

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Abstract
Peanut agglutinin was used in a lectin-anti-lectin immunoperoxidase technique to assess the status of T antigen-like substance in histological sections of benign hyperplasia and adenocarcinoma of the prostate. Of 30 benign lesions, 26 (86.7%) had negative staining in the glandular epithelia and 4 showed uneven staining of the epithelial cells in a small proportion of the glands. Additionally, 15 of 30 benign lesions (50%) had positive staining restricted to the basal myoepithelial cells in variable proportion of the glands. All benign lesions demonstrated the presence of normal cryptic T antigen after neuraminidase digestion. Of 25 adenocarcinomas, 14 (56%) were positive and 7 (25%) were negative for T antigen but demonstrated the presence of normal cryptic T antigen after neuraminidase digestion, and 4 (16%) were negative for T and cryptic T antigens. Of 8 grade 1, 9 grade 2 and 8 grade 3 tumors, and 9 tumors from patients with bone metastases, 3 (37.5 %), 8 (88.9%), 7 (87.5%) and 7 (77.8%), respectively, were positive for T antigen or negative for T and cryptic T antigens. A correlation between the status of T antigen-like substance and tumor grade as well as metastasis in patients with prostatic carcinoma is shown.