Potential Reserpine Analogues: Part II. 3,4,5-Trimethoxybenzoic Acid Derivatives

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Abstract
Seven derivatives of 3,4,5-trimethoxybenzoic acid have been prepared and tested for their ability to potentiate barbiturate hypnosis in mice, to deplete the 5-hydroxytryptamine content of rat brain, and to exert a hypotensive action on the cat blood pressure. The only derivative to exert all three actions is the simple anilide, 3,4,5-trimethoxybenzanilide, which is about 8 times less active than reserpine. The anilide, N-(3,4-dimethoxyphenethyl)-3,4,5-trimethoxybenzamide, is also about 8 times less active than reserpine in the first two tests but it raises the blood pressure.

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