EFFECT OF CALCIUM-CHANNEL BLOCKERS ON ALCOHOL CONSUMPTION IN ALCOHOL-DRINKING MONKEYS
- 1 March 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Alcohol and Alcoholism
- Vol. 26 (2) , 161-167
- https://doi.org/10.1093/oxfordjournals.alcalc.a045097
Abstract
Experiments were performed to determine the effect of the calcium-channel blockers verapamil and diltiazem on ethanol preference in monkeys. Two days of administration of 10 mg/kg verapamil but not diltiazem or saline significantly decreased ethanol intake in all monkeys tested. Chronic treatment with verapamil, but not saline, dose-dependently attenuated alcohol intake, without significantly influencing water intake. These findings suggest that verapamil exerts an inhibitory action on ethanol preference in chronically alcohol-drinking monkeys, possibly by interfering with Ca 2+ -channels and/or by interacting with the activity of certain central neurotransmitters.Keywords
This publication has 0 references indexed in Scilit: