CELL-MEDIATED RESPONSES IN A PORCINE ENTEROVIRUS INFECTION IN PIGLETS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 44  (1) , 61-69
Abstract
Sixteen pathogen-free piglets were infected orally with porcine enterovirus strain T80 and the cell-mediated response to the virus was measured at intervals after infection. Five uninfected piglets were used as controls. Indirect macrophage migration inhibition tests were performed with lymphocytes from blood, ileal lamina propria and mesenteric lymph node. Blood lymphocyte culture supernatants showed no consistent T80 specific effect on macrophage migration, suggesting the absence of a systemic cell-mediated response. Ileal lamina propria lymphocyte culture supernatants showed irregular migration stimulation. The mesenteric lymph node lymphocyte culture supernatants produced migration inhibition at 7 days post-infection followed by stimulation of migration at 10-22 days post-infection. Migration was again inhibited from 24-31 days post-infection. Mesenteric lymph node lymphocyte culture supernatants contained only trace amounts of interferon activity at 28 and 31 days post-infection. The cell-mediated responses in this infection were weak and localized and not associated with significant anti-viral activity.