Mice lacking factor VII develop normally but suffer fatal perinatal bleeding
- 1 November 1997
- journal article
- letter
- Published by Springer Nature in Nature
- Vol. 390 (6657) , 290-294
- https://doi.org/10.1038/36862
Abstract
Blood coagulation in vivo is initiated by factor VII (FVII) binding to its cellular receptor tissue factor (TF)1,2,3,4. FVII is the only known ligand for TF, so it was expected that FVII-deficient embryos would have a similar phenotype to TF-deficient embryos, which have defective vitello-embryonic circulation and die around 9.5 days of gestation5,6,7,8. Surprisingly, we find that FVII-deficient (FVII−/−) embryos developed normally. FVII−/− mice succumbed perinatally because of fatal haemorrhaging from normal blood vessels. At embryonic day 9.5, maternal–fetal transfer of FVII was undetectable and survival of embryos did not depend on TF–FVII-initiated fibrin formation. Thus, the TF−/− embryonic lethal and the FVII−/− survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation.Keywords
This publication has 24 references indexed in Scilit:
- Role of tissue factor in embryonic blood vessel developmentNature, 1996
- Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation.Proceedings of the National Academy of Sciences, 1996
- Hematopoietic Stem Cells in the Mouse Embryonic Yolk SacThe International Journal of Cell Cloning, 1996
- Anticoagulant repertoire of the hookworm Ancylostoma caninum.Proceedings of the National Academy of Sciences, 1996
- Cell biology of tissue factor, the principal initiator of blood coagulationThrombosis Research, 1996
- Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.Proceedings of the National Academy of Sciences, 1995
- Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.Proceedings of the National Academy of Sciences, 1995
- Tissue Factor: Then and NowThrombosis and Haemostasis, 1995
- Regulation of the extrinsic pathway system in health and disease: The role of factor VIIa and tissue factor pathway inhibitorThrombosis Research, 1995
- Models for Placental Transfer Studies of DrugsClinical Pharmacokinetics, 1995