IGG AND IGM ANTICARDIOLIPIN ANTIBODIES IN PATIENTS WITH LUPUS WITH ANTICARDIOLIPIN ANTIBODY ASSOCIATED CLINICAL SYNDROMES

  • 1 January 1988
    • journal article
    • research article
    • Vol. 15  (5) , 795-798
Abstract
IgG and IgM anticardiolipin antibodies (aCL) were measured by a solid phase enzyme immunoassay in 64 patients with systemic lupus erythematosus who had one or more clinical disorders reported to be associated with aCL. We found the presence of IgG aCL was significantly associated with an increased incidence of cerebrovascular disease (p < 0.01), a positive Venereal Disease Research Laboratories (VDRL) test (p < 0.02) and prolonged partial thromboplastin time (PTT) (p < 0.001). IgM aCL were associated with recurrent spontaneous abortion (p < 0.05), thrombocytopenia (p < 0.05) as well as a positive VDRL and prolonged PTT. The combination of high titer IgG and IgM aCL was associated with endocardial disease (p = 0.02), migraine (p < 0.02), in addition to fetal loss (p < 0.001).