5-HT1A receptor function in depression: effect of chronic amitriptyline treatment
- 1 June 1990
- journal article
- research article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 80 (2) , 157-161
- https://doi.org/10.1007/bf01257081
Abstract
Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1Amediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulted during AMI treatment.Keywords
This publication has 13 references indexed in Scilit:
- Pharmacology of the hypothermic response to 5-HT1A receptor activation in humansEuropean Journal of Clinical Pharmacology, 1990
- Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depressionLife Sciences, 1990
- 5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterizationTrends in Neurosciences, 1988
- The effect of 8-OH-DPAT on temperature in the rat and its modification by chronic antidepressant treatmentsPharmacology Biochemistry and Behavior, 1988
- 5-HT1A receptor-related anxiolyticsTrends in Pharmacological Sciences, 1987
- Hypothermia induced by the putative 5-HT1A agonists LY165163 and 8-OH-DPAT is not prevented by 5-HT depletionEuropean Journal of Pharmacology, 1987
- Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the ratPsychopharmacology, 1987
- The pharmacology of the behavioral and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)Psychopharmacology, 1987
- Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the ratNeuropharmacology, 1986
- Nocturnal temperature in affective disorderJournal of Affective Disorders, 1982