Calculating reference intervals for laboratory measurements
- 1 April 1999
- journal article
- research article
- Published by SAGE Publications in Statistical Methods in Medical Research
- Vol. 8 (2) , 93-112
- https://doi.org/10.1177/096228029900800202
Abstract
Reference intervals are used in laboratory medicine to detect measurements which are extreme, possibly abnormal. Methods of estimating reference intervals and age-specific reference intervals (where the measurement is dependent on a covariate, typically age) are reviewed. The issues of calculating confidence bands, determining appropriate sample sizes and assessing goodness-of-fit are discussed.Keywords
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