Syntheses of 3-Deoxy-3-Fluoroglucosamine Derivatives

Abstract
Methyl 2-acetamido-4,6-di-0-acetyl-2,3-dideoxy-3-fluoro-α-D-glucopyranoside (5) and methyl 2-diallylamino-2,3,6-trideoxy-3,6-difluoro-4-0-methanesulfonyl-α-D-glucopyranoside (10) were prepared from methyl 4,6-0-benzylidene-α-D-glucopyranoside. Fluorination at C-3 was carried out by ring opening of an aziridinium ion. Two fluorinating reagents were used depending on the starting material.