Cure of Dysgerminoma with Widespread Metastases Appearing after Renal Transplantation

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Abstract
McKHANN1 recently noted that 13 primary cancers had appeared in approximately 2000 recipients of renal transplants. This figure (5 per 1000 under the age of 40) greatly exceeds the risk in the population (8.2 per 100,000). This increased incidence constitutes evidence that the immune surveillance mechanism against malignant mutations is impaired by immunosuppressive drugs. Almost all patients have died, suggesting a more rapid course of the malignant process in such cases. The present report documents a patient with malignant dysgerminoma with widespread metastases appearing two years after transplantation. The tumor was obliterated by intensive therapy despite the fact that immunosuppressant . . .