Comparison of Quantity of Egg and Mouse-Adapted Influenza Viruses Required to Infect Each Host

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Abstract
Parallel titrations to determine the dilution of virus essential to initiate infection in the allantoic membrane of the embryonated egg and the mouse lung were carried out. In every instance with mouse-adapted viruses, the relative quantity essential to infect the mouse and the chick embryo was approx. the same; with egg-adapted viruses approx. 2 logs more virus were required to initiate multiplication in the mouse lung than in the allantoic sac. These data describe another property of mouse-adapted influenza viruses which distinguish them from unadapted strains.