Dichloroacetate and the Treatment of Lactic Acidosis

Publisher Website
Google Scholar
Abstract
To the Editor: We share the interest in the potential of sodium dichloroacetate as a therapeutic agent in lactic acidosis expressed in the editorial in the March 9 issue of the Journal. The logic of this approach requires careful scrutiny. It seems to us that the aims in treatment of lactic acidosis are twofold. The first is to eliminate the most immediate danger, which in lactic acidosis unaccompanied initially by shock ("Type B" lactic acidosis) is the severe acidosis —no one to our knowledge has produced any evidence that the lactate ion per se is toxic. The most obvious . . .

This publication has 1 reference indexed in Scilit: