Synthesis of 14C‐labelled 5‐hydroxy‐4‐keto‐valeric acid and 4, 5‐dioxo‐valeric acid
- 1 March 1981
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 18 (3) , 433-438
- https://doi.org/10.1002/jlcr.2580180318
Abstract
5‐Hydroxy‐4‐keto [4‐14C]valeric acid was prepared from 5‐amino [4‐14C]levulinic acid. The synthesis of 5‐hydroxy‐4‐keto [1‐14C]valeric acid (4) was achieved by Grignard reaction of 1‐benzyloxy‐4‐bromo‐2‐butanone ethylene acetal (1) with 14CO2 and subsequent removal of the protecting groups.4,5‐Dioxo [1‐ or 4‐14C]valeric acid was made by oxidation of the α‐ketol group with cupric acetate.Keywords
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