Relevance of somatostatin receptors and other peptide receptors in pathology
- 1 March 1997
- journal article
- review article
- Published by Springer Nature in Endocrine Pathology
- Vol. 8 (1) , 11-20
- https://doi.org/10.1007/bf02739703
Abstract
Receptors for regulatory peptides can be overexpressed by several diseases, in particular by neoplasms. This review summarizes the current status of knowledge in this field, on the basis of in vitro receptor studies and with emphasis on receptors for somatostatin as well as for substance P (SP), vasoactive intestinal polypeptide (VIP), and cholecystokinin. It evaluates the existing and potential clinical implications of the findings for diagnosis and therapy and discusses the role of the pathologist in this context.Keywords
This publication has 26 references indexed in Scilit:
- Peptides and growth factors in non-small cell lung cancerPeptides, 1996
- Unexpected high incidence of cholecystokinin-B/gastrin receptors in human medullary thyroid carcinomasInternational Journal of Cancer, 1996
- Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells.Journal of Clinical Investigation, 1996
- Substance‐P receptors in human primary neoplasms: Tumoral and vascular localizationInternational Journal of Cancer, 1995
- Multiple actions of somatostatin in neoplastic diseaseTrends in Pharmacological Sciences, 1995
- Classification and nomenclature of somatostatin receptorsTrends in Pharmacological Sciences, 1995
- Somatostatin analogue scintigraphy in granulomatous diseasesEuropean Journal of Nuclear Medicine and Molecular Imaging, 1994
- In vitro detection of somatostatin receptors in human tumorsMetabolism, 1992
- Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis.Annals of the Rheumatic Diseases, 1992
- Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease.Proceedings of the National Academy of Sciences, 1988