Data-Driven Methods to Discover Molecular Determinants of Serious Adverse Drug Events
- 28 January 2009
- journal article
- review article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 85 (3) , 259-268
- https://doi.org/10.1038/clpt.2008.274
Abstract
The dangers of serious adverse drug reactions (SADRs) are well known to clinicians, pharmacologists, and the lay public. Efforts to elucidate the molecular mechanisms behind SADRs have made significa...Keywords
This publication has 78 references indexed in Scilit:
- Molecular Genetics of Successful Smoking CessationArchives of General Psychiatry, 2008
- The liver pharmacological and xenobiotic gene response repertoireMolecular Systems Biology, 2008
- The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledgeNucleic Acids Research, 2007
- Identification of Genetic Variants Contributing to Cisplatin-Induced Cytotoxicity by Use of a Genomewide ApproachAmerican Journal of Human Genetics, 2007
- A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistanceProceedings of the National Academy of Sciences, 2007
- A strategy for predicting the chemosensitivity of human cancers and its application to drug discoveryProceedings of the National Academy of Sciences, 2007
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature, 2007
- NCBI GEO: mining tens of millions of expression profiles--database and tools updateNucleic Acids Research, 2006
- Genomic signatures to guide the use of chemotherapeuticsNature Medicine, 2006
- Systematic variation in gene expression patterns in human cancer cell linesNature Genetics, 2000