Increased Glomerular Filtration Rate in Patients with Major Burns and Its Effect on the Pharmacokinetics of Tobramycin
- 26 October 1978
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 299 (17) , 915-919
- https://doi.org/10.1056/nejm197810262991703
Abstract
The clearance of endogenous creatinine in 20 burned patients, measured between the fourth and the 35th post-burn day, was a mean (± S.D.) of 172.1 ±48.4 ml per minute per 1.73 m2; in eight normal subjects the mean value was 125.4±10.4 (P<0.02). Thirteen patients had values more than 2 S.D. above the normal mean. We confirmed this rise in glomerular filtration rate by measuring inulin or iothalamate clearance in nine patients.This publication has 16 references indexed in Scilit:
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