DYSPLASIA AND RESERVE CELL HYPERPLASIA‐LIKE CHANGE IN HUMAN ESOPHAGUS

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Abstract
The esophagus was totally examined in 264 autopsied cases and 61 operated cases, for a total of 325 cases, to clarify the histogenesis of squamous cell carcinoma of the esophagus. Epithelial dysplasia of the mucosa was present in 27% and subclinical carcinoma was found in 2.4%. Hyperplasia of the duct of the esophageal gland proper was present in 34% and dysplasia of the ductal epithelium in 3%. Reserve cell hyperplasia-like change of the islet of the ectopic gastric mucosa was found in 4% and reserve cell hyperplasia-like change of the esophagogastric junction zone in 13%. Of the 7 cases of microcarcinoma, 2 showed dysplasia and gradual transition and 1 presented dysplasia and abrupt transition. Another 2 were considered to have originated in the ductal epithelium. The sites mentioned could possibly be the sites of origin of cancer development.