Asymmetric conjugate addition of Grignard reagents in the presence of tertiary amines to α,β-unsaturated amides derived from (S)-2-(1-hydroxy-1-methylethyl)pyrrolidine or (S)-prolinol
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 8,p. 469-470
- https://doi.org/10.1039/c39850000469
Abstract
In the presence of tertiary amines, diastereoselective conjugate addition of Grignard reagents to α,β-unsaturated amides affords 3-substituted carboxylic acids of high enantiomeric excess (up to 89% e.e.).Keywords
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