ELIMINATION OF ACUTE MYELOGENOUS LEUKEMIC-CELLS FROM MARROW AND TUMOR SUSPENSIONS IN THE RAT WITH 4-HYDROPEROXYCYCLOPHOSPHAMIDE
- 1 January 1980
- journal article
- research article
- Vol. 55 (3) , 521-523
Abstract
Cell suspensions of normal rat marrow mixed with rat acute myelogenous leukemic cells were prepared and incubated in vitro with graded doses of 4-hydroperoxycyclophosphamide (4HC). The cell suspensions were injected into rats prepared with a lethal dose of total body irradiation. Animals injected with these cells survived fatal irradiation induced aplasia. In a dose related manner, 4HC was able to purge tumor cells from the cell mixtures. Thus, animals given cell suspensions incubated with the lower doses of 4HC showed prolonged survival before death from leukemia and animals given cell suspensions incubated with higher doses of 4HC survived lethal irradiation without the subsequent appearance of leukemia. Tumor cells may be eliminated from normal marrow suspensions without completely destroying the pluripotent stem cells.This publication has 6 references indexed in Scilit:
- MARROW TRANSPLANTATION FOR PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA IN REMISSION1979
- Bone Marrow Transplantation in Cancer Therapy: Inactivation by Antibody and Complement of Tumor Cells in Mouse Syngeneic Marrow TransplantsExperimental Biology and Medicine, 1978
- CAPACITY OF MICROSOMALLY-ACTIVATED CYCLOPHOSPHAMIDE TO INDUCE IMMUNOSUPPRESSION INVITRO1978
- BN RAT MYELOID-LEUKEMIA TRANSFERRED TO (LEW X BN)F1 RAT1978
- TRANSPLANTATION OF SYNGENEIC BONE MARROW INCUBATED WITH LEUCOCYTE ANTIBODIESTransplantation, 1977
- IDENTIFICATION OF ALDOPHOSPHAMIDE AS A METABOLITE OF CYCLOPHOSPHAMIDE INVITRO AND INVIVO IN HUMANS1977