A New Scalarane Sesterterpenoid from the Marine Sponge Cacospongia mollior
- 1 February 1994
- journal article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 57 (2) , 256-262
- https://doi.org/10.1021/np50104a010
Abstract
A new sesterterpene, 12-deacetoxyscalaradial [2a] has been isolated from the sponge Cacospongia mollior, together with the previously described scalaradial [2b] and furoscalarol [3]. The structure of the new compound, proposed by spectral data, was confirmed by X-ray diffraction analysis. Compound 2a is the first scalarane sesterterpenoid, without a substituent at C-12, to have been identified in nature. It shows high antifeedant activity and is hot to taste for the human tongue. Both 2a and 2b display cytotoxic activity.Keywords
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