The Release of Histamine from the Pars Flaccida Mast Cells One Cause of Otitis Media with Effusion?

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Abstract
In this experimental study in the rat, compound 48/80-a potent degranulating drug of mast cells-was instilled in the external auditory meatus towards the tympanic membrane. Moreover, effusion material was produced in the attic space by blocking the tympanic isthmus with a piece of Gelfoam applied through the tympanic bulla. Both these procedures caused a degranulation of the pars flaccida mast cells and subsequently histamine was detected in the rinsing fluid collected from the middle ear cavity. A possible direct cause of the effusion material in the middle ear cavity may be a degranulation of the pars flaccida mast cells, thus resembling an allergic reaction Type I.