The EEG Effects of Chemically and Clinically Dissimilar Antipsychotics — Molindone vs. Chlorpromazine

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Abstract
EEG studies were conducted in 35 out of 44 chronic schizophrenic patients, both men and women, who participated in a 3-month, double-blind, placebo controlled study of MOL and CPZ. It was found that the CPZ subjects, who showed the greatest clinical improvement, showed also the greatest EEG changes (slower and more abundant a, emergence of 0), whereas MOL, although different from PL in the amount of slow a present, did not show significant increase in the 0-rhythm. In this respect the EEG changes paralleled the clinical changes. The possibility of an electroclinical association between alerting behavioral effects of some antipsychotics (MOL, Haloperidol) and the absence of 0 was suggested.

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