Study on Nine Families with Haemoglobin Lepore in Campania

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Abstract
Nine families, including 19 heterozygous, 1 homozygous and 1 double heterozygous (Hb Lepore + beta thalassaemia) subjects, were studied. After the thalassemia and sicklemia, the Hb Lepore appears to be the most frequent hemoglobin anomaly in this region. The thalassaemia-like picture of the erythrocytes, the Hb F growth and the tendency to lower Hb A2 levels in the Hb Lepore carriers were confirmed. A case of homozygosity for Hb Lepore is discussed. The blood pigment of this 4 year-old patient consisted exclusively of Hb Lepore (30%) and Hb F (70%). In opposition to the other 3 cases already known this child did not present the Cooley''s features. The Hb Lepore variants can differ from one another.