Drosophila S6 Kinase: A Regulator of Cell Size
- 24 September 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 285 (5436) , 2126-2129
- https://doi.org/10.1126/science.285.5436.2126
Abstract
Cell proliferation requires cell growth; that is, cells only divide after they reach a critical size. However, the mechanisms by which cells grow and maintain their appropriate size have remained elusive.Drosophila deficient in the S6 kinase gene (dS6K) exhibited an extreme delay in development and a severe reduction in body size. These flies had smaller cells rather than fewer cells. The effect was cell-autonomous, displayed throughout larval development, and distinct from that of ribosomal protein mutants (Minutes). Thus, the dS6K gene product regulates cell size in a cell-autonomous manner without impinging on cell number.Keywords
This publication has 35 references indexed in Scilit:
- Coordination of Growth and Cell Division in the Drosophila WingCell, 1998
- Another role rolls inNature, 1996
- Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathwayNature, 1995
- Interaction between dorsal and ventral cells in the imaginal disc directs wing development in DrosophilaCell, 1993
- Control of the yeast cell cycle by the Cdc28 protein kinaseCurrent Opinion in Cell Biology, 1993
- A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinaseCell, 1992
- Changing spatial patterns of DNA replication in the developing wing of DrosophilaDevelopmental Biology, 1987
- Genetic Transformation of Drosophila with Transposable Element VectorsScience, 1982
- Cell cycle changes during growth and differentiation of imaginal leg discs in Drosophila melanogasterDevelopmental Biology, 1982
- Alterations in the cell cycle of Drosophila imaginal disc cells precede metamorphosisDevelopmental Biology, 1982