Experiments With Phenylhydrazine

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Abstract
Dogs were given phenylhydrazine hydro-chloride for 146 days in 8 months and a total dosage comparable to 4-6 yrs. of treatment of polycythemia vera in man. The response of the total number of leukocytes was irregular, with a tendency to increase. In some cases this seemed to be due to the specific action of the drug. There was an irregular response in the absolute number of neutrophils, lymphocytes, eosinophils, transitionals, and mononuclears and there was in most instances a rough parallelism between changes in the numbers of these cells and in total number of leukocytes. Transitional cells uniformly increased in percentage, while change in percentage of neutrophils was irregular. Percentage of lymphocytes followed in inverse proportion to percentage of neutrophils. There was little change in the number of mono-nuclear cells and eosinophils. Each mgm. of phenylhydrazine for each kgm. of body weight caused a decrease of as much as 38,000 erythrocytes when large doses were given and as little as 9,000 when smaller doses were given over long periods. An amount of phenylhydrazine sufficient to cause a reduction in the original amount of erythrocytes failed to further reduce the number of erythrocytes when a variable low level was reached.

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