Synthesis of 5-(acylethynyl)uracils and their corresponding 2′-deoxyribonucleosides through palladium-catalysed reactions
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 21,p. 2657-2663
- https://doi.org/10.1039/p19930002657
Abstract
Good yields of the title uracils were obtained by using the palladium-catalysed reaction between 5-iodo-2,4-dimethoxypyrimidine and substituted propargylic alcohols rather than the corresponding ketones. The same strategy works for coupling with the 5-iodo-2′-deoxyuridines.Keywords
This publication has 66 references indexed in Scilit:
- Synthesis and biological activities of [E]-5-(2-acylvinyl)uracilsEuropean Journal of Medicinal Chemistry, 1993
- Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cellsJournal of Medicinal Chemistry, 1989
- The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related ComplexNew England Journal of Medicine, 1987
- 5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogJournal of Medicinal Chemistry, 1985
- 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.Proceedings of the National Academy of Sciences, 1985
- Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogsPharmacology & Therapeutics, 1984
- Antiviral, antitumor, and thymidylate synthetase inhibition studies of 5-substituted styryl derivatives of 2′-deoxyuridine and their 5′-phosphatesBiochemical Pharmacology, 1981
- (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.Proceedings of the National Academy of Sciences, 1979
- Synthesis and biological activity of several amino analogs of thymidineJournal of Medicinal Chemistry, 1978
- Nucleosides. V. The Monomesylates of 1-(2'-Deoxy-β-D-lyxofuranosyl)thymine1,2The Journal of Organic Chemistry, 1964