URETHANE (ETHYL CARBAMATE) THERAPY IN MULTIPLE MYELOMA

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Abstract
Four patients with multiple myeloma were treated with urethane for 8-10 wks. in total doses of 120-290 g. with marked therapeutic benefits. Fever, bone pain and acute symptoms subsided after 2-4 wks. There was a disappearance of immature granulocytes and nucleated red blood cells from the circulating blood of individuals with severe anemia, with improvement of other blood values. There was a decrease in the number of bone marrow myeloma cells, with return towards normal of serum protein values, albuminuria and Bence-Jones substance excretion. There was no progression of skeleton lesions, but there was little evidence of recalcification.