Alterations in Lipogenic Enzymes and Lipoprotein Lipase Activity During Gram-Negative Sepsis in the Rat

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Abstract
• The effects of sepsis on lipid metabolism have not been clearly defined. This study was designed to observe the changes in adipose tissue lipoprotein lipase (LPL) and fatty acid synthetase (FAS) after administration ofEscherichia colibacteria. Male Lewis rats, weighing 245 to 270 g, were assigned to two groups and fed a powdered chow diet for 14 days. On day 14, one group was inoculated withE coli. Twenty-four hours later, both groups were killed by decapitation. Serum triglyceride levels were significantly elevated in theE coli–treated rats. Adipose tissue LPL and FAS activity was significantly decreased by 50% inE coli–treated rats compared with the control rats. These results suggest that the elevated serum triglyceride levels associated with sepsis may be caused by a decreased rate of clearance of lipids from the blood and an increased rate of hepatic lipid synthesis. (Arch Surg1982;117:144-147)