Brain Amine Concentrations after Monoamine Oxidase Inhibitor Administration
- 1 January 1972
- Vol. 1 (5791) , 17-19
- https://doi.org/10.1136/bmj.1.5791.17
Abstract
The concentrations of 5-hydroxytryptamine (5HT), noradrenaline, and dopamine were estimated post mortem in brain stem, hypothalamus, and caudate nucleus in 33 patients who had been treated with isocarboxazid, clorgyline, or tranylcypromine and 11 controls. Similar and highly significant increases in 5HT and noradrenaline concentration occurred with all three drugs. The distribution was unimodal, but about a quarter of the patients showed only a small increase in brain amines. Tranylcypromine seemed to have a significantly greater effect on dopamine in caudate nucleus and hypothalamus compared with isocarboxazid and clorgyline. In the doses used chlorpromazine did not reduce the amine concentrations. Four patients with Parkinson's syndrome had low concentrations of dopamine in caudate nucleus in spite of monoamine oxidase inhibitor administration.Keywords
This publication has 16 references indexed in Scilit:
- Effect of L-DOPA on brain monoamines and their metabolites in Parkinson's diseaseLife Sciences, 1971
- EFFECT OF THYROID HORMONE ON THE BIOCHEMICAL MATURATION OF RAT BRAIN: CONVERSION OF GLUCOSE‐CARBON INTO AMINO ACIDSJournal of Neurochemistry, 1970
- Mono-amine oxidase inhibitors, sleep and moodElectroencephalography and Clinical Neurophysiology, 1970
- Multiple Forms of Human Brain Mitochondrial Monoamine OxidaseNature, 1970
- Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapyBMJ, 1969
- Multiple Forms of Rat Brain Monoamine OxidaseNature, 1969
- 5-HYDROXYTRYPTAMINE, NORADRENALINE, AND DOPAMINE IN BRAINSTEM, HYPOTHALAMUS, AND CAUDATE NUCLEUS OF CONTROLS AND OF PATIENTS COMMITTING SUICIDE BY COAL-GAS POISONINGThe Lancet, 1969
- Further studies on the inhibition of monoamine oxidase by M & B 9302 (clorgyline)—I: Substrate specificity in various mammalian speciesBiochemical Pharmacology, 1969
- Intramuscular nialamide in depressed patients (a biochemical study).1966
- A clinical analysis of the effects of tofranil in depressionPsychopharmacology, 1961