Metacarpophalangeal pattern profile analysis in Prader-WiIIi syndrome
- 23 April 2008
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 22 (6) , 315-320
- https://doi.org/10.1111/j.1399-0004.1982.tb01846.x
Abstract
Metacarpophalangeal pattern profile (MCPP) was determined on 16 Prader-Willi patients. Chromosome analysis of 14 patients showed an interstitial deletion of the long arm of chromosome 15 in 7 subjects and normal chromosome results for the remaining individuals. Two separate and distinguishable hand profiles for each group based on the chromosome findings were identified. Correlation studies confirmed the homogeneity of the chromosome deletion group relative to the Prader-Willi individuals with normal chromosomes. Discriminant analysis of Prader-Willi vs. normal individuals produces a function of 3 MCPP variables plus age which may provide a useful tool for diagnosis.Keywords
This publication has 8 references indexed in Scilit:
- The acrocephalosyndactyly syndromes: A metacarpophalangeal pattern profile analysisClinical Genetics, 2008
- Deletions of Chromosome 15 as a Cause of the Prader–Willi SyndromeNew England Journal of Medicine, 1981
- The hand profile in de Lange syndrome: Diagnostic criteriaAmerican Journal of Medical Genetics, 1979
- Metacarpophalangeal Length in the Evaluation of Skeletal MalformationRadiology, 1972
- Metacarpophalangeal Pattern Profiles in the Evaluation of Skeletal MalformationsRadiology, 1972
- Das Prader-Labhart-Willi-Syndrom (Myatonischer Diabetes)Published by Springer Nature ,1971
- Hypotonia, mental retardation, obesity, and cryptorchidism associated with dwarfism and diabetes in children.Archives of Disease in Childhood, 1967
- Prader‐Willi Syndrome in Boy of Ten with PrediabetesActa Paediatrica, 1964