125I-fibrinogen uptake following phlebography of the leg. Comparison of ionic and nonionic contrast media.

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Abstract
The incidence of venous thrombosis diagnosed with the 125I-fibrinogen uptake test was investigated in a prospective, randomized, double-blind study with the patient serving as his own control using an ionic contrast medium (methylglucamine iothalamate 280) in 1 leg and a nonionic medium (metrizamide) in the other. The incidence of thrombosis was significantly lower with metrizamide (7%) than with methylglucamine iothalamate (28.6%). Metrizamide is the contrast medium of choice for phlebography. [The toxicity of the 2 radiopharmaceuticals was compared].