Deletion mapping and linkage analysis provide strong indication for the involvement of the human chromosome region 8p12-p22 in breast carcinogenesis
Open Access
- 1 October 1997
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 76 (8) , 983-991
- https://doi.org/10.1038/bjc.1997.497
Abstract
We have identified a high frequency of loss of heterozygosity (LOH) on the human chromosome region 8p12-p22 in a panel of microdissected familial (86% LOH) and sporadic (74% LOH) breast tumours. The two most frequently deleted regions were defined around marker D8S133 and in a broader centromeric region bounded by markers D8S137 and D8S339. We cannot unequivocally characterize the 8p12-p22 loss as an early or a late event in breast carcinogenesis. In parallel, we have performed linkage analysis in four German breast cancer families. A location score greater than 13.67 corresponding to a LOD score of 2.97 at the marker D8S137 has been obtained. Our results considerably strengthen the evidence for a breast cancer susceptibility gene(s) located on the short arm of the chromosome region at 8p12-p22.Keywords
This publication has 32 references indexed in Scilit:
- Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer familiesOncogene, 1997
- A comprehensive genetic map of the human genome based on 5,264 microsatellitesNature, 1996
- Integrated Map of the Chromosome 8p12–p21 Region, a Region Involved in Human Cancers and Werner SyndromeGenomics, 1996
- Analysis of CA repeat polymorphisms places three human gene loci on the 8p linkage mapCytogenetic and Genome Research, 1996
- The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set–recoding and fuzzy inheritanceNature Genetics, 1995
- Localization of a tumor suppressor gene associated with progression of human prostate cancer within a 1.2 Mb region of 8p22‐p21.3Genes, Chromosomes and Cancer, 1995
- Loss of heterozygosity from the short arm of chromosome 8 is an early event in breast cancersGenes, Chromosomes and Cancer, 1995
- A 3‐Mb physical map of the chromosome region 8p21.3‐p22, including a 600‐kb region commonly deleted in human hepatocellular carcinoma, colorectal cancer, and non‐small cell lung cancerGenes, Chromosomes and Cancer, 1994
- Deletion mapping reveals two regions of chromosome 8 allele loss in colorectal carcinomasGenes, Chromosomes and Cancer, 1994
- Deletion mapping of the short arm of chromosome 8 in non‐small cell lung carcinomaGenes, Chromosomes and Cancer, 1993