Cyclic 3?,5?-adenosine monophosphate level and adenylate cyclase activity in human blood platelets during storage in ACD solution
- 1 April 1977
- journal article
- research article
- Published by Springer Nature in Annals of Hematology
- Vol. 34 (4) , 329-332
- https://doi.org/10.1007/bf00996209
Abstract
The level of cyclic 3′,5′-adenosine monophosphate (cAMP) in human blood platelets and the activity of platelet adenylate cyclase in response to prostaglandin E1 stimulation do not change during two days storage at room temperature in ACD solution. However, the level of cyclic AMP is lower in platelets stored in ACD solution than in platelets from blood anticoagulated by ethylenediamine tetra-acetic acid. Die Konzentration von zyklischem AMP und die Aktivität der Adenylat-Zyklase nach Stimulation mit Prostaglandin E1 in menschlichen Thrombozyten ändert sich nicht, wenn diese zwei Tage bei Zimmertemperatur in ACD-Lösung gelagert werden. Die Konzentration von zyklischem AMP in derart gelagerten Blutplättchen ist niedriger als in Thrombozyten, die aus EDTA ungerinnbar gemachtem Blut gewonnen werden.Keywords
This publication has 2 references indexed in Scilit:
- A simple direct assay for cyclic amp in plasma and other biological samples using an improved competitive protein binding techniqueClinica Chimica Acta; International Journal of Clinical Chemistry, 1974
- Divergent effects of epinephrine and prostaglandin E1 on the level of cyclic AMP in human blood plateletsPharmacological Research Communications, 1969