Dopamine D4 Receptors
Open Access
- 1 January 2000
- journal article
- review article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 82 (1) , 1-14
- https://doi.org/10.1254/jjp.82.1
Abstract
Initial investigations on dopamine D4 receptors generated much interest in the role of this receptor in schizophrenia and other aspects of human behavior, as well as new opportunities for novel therapeutics. However, attempts to treat patients suffering from schizophrenia with dopamine D4 agents have failed to yield satisfactory results so far. An examination of the dopamine D4 literature shows that contrasting and conflicting data seemed to be the norm in this field of research. This paper reviews the literature on the dopamine D4 receptor and discusses many of the associated methodological problems that might have contributed to the paradoxical findings.Keywords
This publication has 80 references indexed in Scilit:
- No difference in the expression of the D4 gene in post-mortem frontal cortex from controls and schizophrenicsNeuroscience Letters, 1996
- Characterization of a novel iodinated ligand, IPMPP, for human dopamine D4 receptors expressed in CHO cellsLife Sciences, 1996
- The relative abundance of dopamine D4 receptor mRNA in post mortem brains of schizophrenics and controlsSchizophrenia Research, 1996
- The world-wide distribution of allele frequencies at the human dopamine D4 receptor locusHuman Genetics, 1996
- Lack of association between dopamine D4 receptor gene and schizophreniaAmerican Journal of Medical Genetics, 1995
- Genomic structure and tissue distribution of the mouse dopamine D4 receptorNeuroscience Letters, 1995
- Long-term haloperidol elevates dopamine D4 receptors by 2-fold in ratsEuropean Journal of Pharmacology: Molecular Pharmacology, 1995
- Molecular cloning and characterisation of the gene encoding the murine D4dopamine receptorFEBS Letters, 1995
- Polymorphism in the human dopamine D4 receptor gene (DRD4) in Japanese detected by PCRHuman Molecular Genetics, 1993
- Unusual acute effects of antidepressants and neuroleptics on S2-serotonergic receptorsLife Sciences, 1983