A reliable method of histomorphometric evaluation was developed for comparative investigations on cross sections of normal and pathologically altered human ureters. The reproducibility of the measurements with our rating method was good. In addition to the total area of proximal ureteral cross sections, the proportion of lumen, epithelium, submucosa, and muscularis was determined. Connective tissue, musculature, and edema in the ureteral wall were differentiated by staining. This differentiation, like the counting of inflammatory infiltrates, was done in predefined sectors. Measuring results were summarized in one table. The procedure was illustrated in two diagrams.