Specific Temporal Profile of Matrix Metalloproteinase Release Occurs in Patients After Myocardial Infarction
Top Cited Papers
- 5 September 2006
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 114 (10) , 1020-1027
- https://doi.org/10.1161/circulationaha.105.600353
Abstract
Background— Changes in matrix metalloproteinase (MMP) and tissue inhibitors of MMPs (TIMPs) contribute to left ventricular (LV) remodeling after myocardial infarction (MI). We tested the hypothesis that a specific plasma MMP/TIMP profile would emerge after MI and be associated with the degree of LV dilation. Methods and Results— LV end-diastolic volume and MMP/TIMP plasma profiles were determined in 53 age-matched control subjects and 32 post-MI patients from day 1 through 180 after MI. LV end-diastolic volume increased by >38% at day 90 after MI ( P 150% from control at day 1 after MI ( P 120% at day 3 after MI ( P 60% from control at day 1 after MI ( P P Conclusions— A specific temporal pattern of MMP/TIMPs occurred in post-MI patients that included an early and robust rise in MMP-9 and MMP-8 and a uniform fall in TIMP-4. These findings suggest that a specific MMP/TIMP plasma profile occurs after MI and holds both prognostic and diagnostic significance.Keywords
This publication has 24 references indexed in Scilit:
- Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart studyEuropean Heart Journal, 2004
- Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures - The Framingham Heart StudyCirculation, 2004
- MT1‐MMP: A tethered collagenaseJournal of Cellular Physiology, 2004
- Selective Targeting and Timing of Matrix Metalloproteinase Inhibition in Post-Myocardial Infarction RemodelingCirculation, 2003
- ERK1/2 mediates TNF‐α‐induced matrix metalloproteinase‐9 expression in human vascular smooth muscle cells via the regulation of NF‐κB and AP‐1: Involvement of the ras dependent pathwayJournal of Cellular Physiology, 2003
- Region- and Type-Specific Induction of Matrix Metalloproteinases in Post–Myocardial Infarction RemodelingCirculation, 2003
- Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathyJournal of the American College of Cardiology, 2002
- Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarctionJournal of Clinical Investigation, 2000
- Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix MetalloproteinasesCritical Reviews™ in Eukaryotic Gene Expression, 1997
- Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4Journal of Biological Chemistry, 1996