Effect of aminoguanidine, chlorpromazine and NSD‐1055 on gastric secretion and ulceration in the Shay rat
- 1 January 1971
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 41 (1) , 167-169
- https://doi.org/10.1111/j.1476-5381.1971.tb09946.x
Abstract
Both chlorpromazine and NSD‐1055 (a non‐steroidal anti‐inflammatory drug) markedly lower the volume and acidity of gastric contents of rats subjected to pyloric ligation (Shay technique) and reduce the degree of ulceration in the stomach. On the other hand, aminoguanidine (an inhibitor of histaminase) has no effect on acid secretion or ulceration in these animals.Keywords
This publication has 22 references indexed in Scilit:
- THE EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON HISTAMINE FORMATION IN THE RATBritish Journal of Pharmacology, 1968
- THE EFFECT OF AMINOGUANIDINE, HISTAMINE, CHLORPROMAZINE AND ANTIBACTERIAL AGENTS ON HISTIDINE DECARBOXYLASE IN THE STOMACH OF THE RATBritish Journal of Pharmacology, 1968
- Histidine decarboxylase in the stomach of the ratJournal of Pharmacy and Pharmacology, 1967
- Inhibition of histamine methyltransferase by serotonin and chlorpromazine derivatives: Electronic aspectsBiochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1966
- EFFECTS OF CHLORPROMAZINE AND BROMOLYSERGIC ACID DIETHYLAMIDE ON GASTRIC SECRETION OF ACID INDUCED BY HISTAMINE IN RATSBritish Journal of Pharmacology and Chemotherapy, 1964
- A Quaternary Atropine DerivativeActa Pharmacologica et Toxicologica, 1964
- Histamine and Gastric SecretionPublished by Wiley ,1956
- Comparison of the Atropin‐Iike Actions of some Quaternary Ammonium Compounds and their Effects on “Shay Rats”.Acta Pharmacologica et Toxicologica, 1953
- EFFECTS OF VAGOTOMY IN THE RATArchives of Surgery, 1949
- THE EXPERIMENTAL PRODUCTION OF PEPTIC ULCERAnnals of Surgery, 1923