Highly Diastereoselective 1,4-Addition of Amines to Chiral α,β-Unsaturated δ-Lactone
- 1 May 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 20 (5) , 793-794
- https://doi.org/10.1246/cl.1991.793
Abstract
Michael addition of amines to (S)-γ-amino-α,β-unsaturated δ-lactone was accomplished in extremely high diastereoselectivity with the ring-opening reactions and was disclosed to furnish (3R,4S)-diamino-hydroxyamides in high yields.Keywords
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