Anti-β2-glycoprotein I antibodies
- 1 February 1998
- journal article
- review article
- Published by SAGE Publications in Lupus
- Vol. 7 (2_suppl) , 98-102
- https://doi.org/10.1177/096120339800700222
Abstract
The relationship between presence of anti-β2-glycoprotein I autoantibodies (aβ2-GPI) and history of thrombosis is now widely known. However, differences in the methodology of aβ2-GPI detection have made the comparison of data from different laboratories extremely difficult. We discuss the significance of aβ2-GPI of the IgG, IgM and IgA isotypes, and our approach to developing an easier and more reproducible method for the detection of this autoantibody. In addition, we present data that shows that commercially available enzyme immunoassay plates differ regarding detectability of aβ2-GPI. Since the clinical significance of this heterogeneity is presently unclear, the set-up of the detection systems and interpretation of data need great care.Keywords
This publication has 16 references indexed in Scilit:
- Antibodies to β2-glycoprotein I—a specific marker for the antiphospholipid syndromeClinical and Experimental Immunology, 1997
- Specificity of ELISA for antibody to beta 2-glycoprotein I in patients with antiphospholipid syndromeRheumatology, 1996
- Antibodies to β2‐glycoprotein I and clinical manifestations in patients with systemic lupus erythematosusArthritis & Rheumatism, 1996
- The use of an anti‐β2‐glycoprotein‐I assay for discrimination between anticardiolipin antibodies associated with infection and increased risk of thrombosisBritish Journal of Haematology, 1995
- β2‐Glycoprotein i reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndromeArthritis & Rheumatism, 1994
- Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.The Journal of Experimental Medicine, 1994
- What is the "true" antigen for anticardiolipin antibodies?The Lancet, 1991
- Anticardiolipin cofactor(s) and differential diagnosis of autoimmune diseaseThe Lancet, 1990
- Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).Proceedings of the National Academy of Sciences, 1990
- Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactorThe Lancet, 1990