Sample size requirements for case-control study designs
Open Access
- 19 November 2001
- journal article
- research article
- Published by Springer Nature in BMC Medical Research Methodology
- Vol. 1 (1) , 11
- https://doi.org/10.1186/1471-2288-1-11
Abstract
Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction. The formulas are extended from one control per case to F controls per case and adjusted for a potential multi-category confounder in unmatched or matched designs. Interactive FORTRAN programs are described which compute the formulas. The effect of potential disease-exposure-confounder interaction may be explored. Software is now available for computing adjusted sample sizes for case-control designs.Keywords
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