MATERNAL IMMUNITY TO INFECTIOUS BOVINE-RHINOTRACHEITIS AND BOVINE VIRAL DIARRHEA VIRUSES - DURATION AND EFFECT ON VACCINATION IN YOUNG CALVES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 39  (2) , 241-244
Abstract
The immune response to modified live-virus bovine viral diarrhea (BVD) vaccine and infectious bovine rhinotracheitis (IBR) vaccine was examined in calves that received passive maternal antibodies to these viruses. Blood serum samples from vaccinated and control (nonvaccinated) calves were examined for more than 1 yr to determine the rate of decline of passive anti-BVD and anti-IBR antibodies and the effect that vaccination had on these antibody titers. The control calves lost their antibodies to BVD and IBR viruses at the rate of 1/2 their remaining antibody titer every 21 days. Calves serologically responded to BVD vaccine at a time when maternal antibody titers remained between 1:96 and 1:20. Animals did not seroconvert to the IBR vaccine until maternal antibodies had decreased and become undetectable. Although passive immunity will inhibit IBR vaccination, priming for a secondary response will occur so that on subsequent vaccination, at a time when maternal antibodies have disappeared, the animals will respond anamnestically to IBR vaccination.

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