ESTABLISHMENT AND CHARACTERIZATION OF AN EPSTEIN-BARR VIRUS-NEGATIVE LYMPHOMA B-CELL LINE FROM A PATIENT WITH A DIFFUSE LARGE CELL LYMPHOMA

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (4) , 1368-1373
Abstract
A cell line (LNPL) was established from a tumor biopsy of a nasopharyngeal histiocytic lymphoma composed of large noncleaved B-cells. LNPL expressed Ig M k surface Ig as did the original tumor. LNPL also expressed Ia antigen but lacked Epstein-Barr virus nuclear antigen. It exhibited a translocation between chromosomes 8 and 14 which has been described in certain other malignant lymphoproliferative disorders. An autologous T-Cell line lacked the translocation between chromosomes 8 and 14. LNPL is being used as an immunogen to produce monoclonal antibodies. Such cell lines may facilitate identification of lymphoma-associated surface antigens.