Aggregation Inhibitory Activity of Minor Acetophenones from Paeonia Species
- 1 October 1999
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 65 (7) , 595-599
- https://doi.org/10.1055/s-1999-14030
Abstract
Two minor acetophenones, 2,5-dihydroxy-4-methoxyacetophenone ( 2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD 2 from arachidonic acid.Keywords
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