Host and Bacterial Factors Associated with Haemophilus influenzae Type b Disease in Minnesota Children Vaccinated with Type b Polysaccharide Vaccine
- 30 April 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 159 (5) , 908-916
- https://doi.org/10.1093/infdis/159.5.908
Abstract
Host and bacterial factors were evaluated among 86 Minnesota children with Haemophilus influenzae type b disease detected by active surveillance after introduction of type b polysaccharide vaccine in the state. Children were 2-6 y of age. Thirty-three (38%) had been vaccinated. There was no significant difference between the frequency of low serum concentrations of IgM, IgA, IgG, or IgG2 in the vaccinated and nonvaccinated subjects (13% vs. 8%, P = .5). The presence of the Gm immunoglobulin allotype phenotype (1,3,17;23;5,13,21), previously associated with a lower relative risk of vaccine failure in children from other states, was associated with a fourfold decrease in the relative risk of vaccine failure in Minnesota (P < .07). Haemophilus isolates from 58 of the children were available for clonal characterization by multilocus electrophoresis and outer membrane protein subtyping. There were no significant differences between the clone distribution of the strains causing disease in vaccinated and nonvaccinated patients, and nearly all disease-producing clones in Minnesota also are known to cause disease in other areas of the country. Thus, vaccine failure in Minnesota is infrequently associated with hypogammaglobulinemia or with infection by unusual clones of a H. influenzae type b. Also, the Gm phenotype associated with protection against vaccine failure in other areas of the USA appears to be protective in Minnesota.This publication has 22 references indexed in Scilit:
- Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.Journal of Clinical Investigation, 1984
- Prevention ofHemophilus influenzaeType B Bacteremic Infections with the Capsular Polysaccharide VaccineNew England Journal of Medicine, 1984
- Histocompatibility Leukocyte Antigen and Erythrocyte MNSs Specificities in Patients with Meningitis or Epiglottitis Due to Haemophilus influenzae Type bThe Journal of Infectious Diseases, 1984
- IGA BLOCKS IGM AND IGG-INITIATED IMMUNE LYSIS BY SEPARATE MOLECULAR MECHANISMS1983
- Gm and Km frequencies in a Portugese populationHuman Genetics, 1982
- Subtyping Isolates of Haemophilus influenzae Type b by Outer-Membrane Protein ProfilesThe Journal of Infectious Diseases, 1981
- Meningitis Caused by Haemophilus influenzae in Infant Rats: Protective Immunity and Antibody Priming by Gastrointestinal Colonization with Escherichia coliThe Journal of Infectious Diseases, 1979
- Association between cross-reacting Escherichia coli K100 and disease caused by Haemophilus influenzae type bInfection and Immunity, 1978
- HEMOPHILUS-INFLUENZAE TYPE-B CAPSULAR POLYSACCHARIDE VACCINE IN CHILDREN - DOUBLE-BLIND FIELD-STUDY OF 100,000 VACCINEES 3 MONTHS TO 5 YEARS OF AGE IN FINLAND1977
- HOST FACTORS AND ANTIBODY-RESPONSE IN HEMOPHILUS-INFLUENZAE TYPE-B MENINGITIS AND EPIGLOTTITIS1976