Some Effects of Prostaglandins E2 and F2α on the Pregnant Rhesus Monkey1
Open Access
- 1 October 1970
- journal article
- research article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 3 (2) , 163-168
- https://doi.org/10.1093/biolreprod/3.2.163
Abstract
Prostaglandin E2(PGE2) or prostaglandin F2α (PGF2α) was injected subcutaneously or infused intravenously into pregnant rhesus monkeys. Animals were between day 30 and 127 of pregnancy; pregnancy termination, serum progestin levels, and uterine contractility were parameters measured to determine efficacy. Subcutaneous injections of PGF2α or PGE2 terminated pregnancy in 8 of 13 animals when given between day 30 and 41 and beyond day 100 of pregnancy. Intravenous infusion terminated 3 of 7 animals between day 30 and 40 of pregnancy. Progestin levels were usually depressed within 24–48 hr after the initial administration of prostaglandin, whereas uterine contractility was increased within 20–30 min. Prostaglandin E2 was about 10 times as potent as PGF2α in causing uterine contractions; intravenous infusion of 0.8 and 8.0 μg/min, respectively, caused maximal uterine contractions during the latter half of pregnancy. The realtionship of these compounds to normal pregnant uterine physiology in the human and rhesus monkey is discussed.Keywords
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