New advances in the understanding of the role of steroids and steroid receptors in disease
- 1 April 2001
- journal article
- review article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 29 (2) , 205-9
- https://doi.org/10.1042/0300-5127:0290205
Abstract
Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, is associated with a decreased breast cancer risk. This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-beta.Keywords
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