Phenolic Compounds with Anti-Inflammatory Activity fromEupatorium buniifolium
- 9 November 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 67 (08) , 743-744
- https://doi.org/10.1055/s-2001-18355
Abstract
Anti-inflammatory activity was detected in the CH2Cl2 extract of the aerial parts of Eupatorium buniifolium using the TPA-mouse ear model. Three compounds isolated from this extract, by bioassay-guided fractionation, significantly inhibited the inflammatory response. The compounds were identified as 5,7,5′-trihydroxy-3,6,2′,4′-tetramethoxyflavone (1), scopoletin (2) and centaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49.7 %, respectively, at a dose of 1 mg/ear.Keywords
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