Powder Flow Studies II. Powder Compactibility Factor Pnd its Relationship to Powder Flow

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Abstract
The powder compactibility factors of a drug, an experiment and several drug-experiment combinations were detemined by plottlng the logarithm of the change in the powder bed volume contained in cylindrical containers versus logarithm of the applied pressure. The powder compactibility factor increased as the powder bulk density decreased and the plots of these two properties were linear at lower powder bulk densities. The plots of the logarithm of flow rate and the coefficient of variation versus the compactibility factor were also linear Indicating the usefulness of this method in predicting flow properties of powders and powder mixtures.

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