Temporal Relationship of Viral Load, Ribavirin, Interleukin (IL)–6, IL‐8, and Clinical Progression in Patients with Severe Acute Respiratory Syndrome
Open Access
- 1 October 2004
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 39 (7) , 1071-1075
- https://doi.org/10.1086/423808
Abstract
Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)—6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.Keywords
This publication has 13 references indexed in Scilit:
- Detection of SARS-associated Coronavirus in Throat Wash and Saliva in Early DiagnosisEmerging Infectious Diseases, 2004
- Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patientsClinical Microbiology & Infection, 2004
- Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS PatientsEmerging Infectious Diseases, 2004
- The Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysisBMJ, 2003
- Clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto AreaJAMA, 2003
- Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirusThe Lancet, 2003
- A Novel Coronavirus Associated with Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- A Major Outbreak of Severe Acute Respiratory Syndrome in Hong KongNew England Journal of Medicine, 2003